Colombia’s REDD+ Readiness Preparation Proposal (R-PP) identifies the main drivers of deforestation and degradation as being the extension of agricultural and livestock frontiers, illicit crops, settlements or displacement of populations, infrastructure, and mining, among other aspects. This paper argues that, despite the factors which continue to threaten the integrity, resilience and expanse of Colombia’s remaining forests Colombia has an excellent opportunity to enact measures that can continue to sustain its rich forest heritage and contain deforestation and degradation activities. To reduce the current deforestation rate, the outlines country-level REDD+ readiness efforts proposed to give a multi-sectoral, inter-institutional approach to each set of drivers, the reduction of perverse incentives associated with deforestation and forest degradation, the increase of overall policy coherence between sectors, and a nested approach.