This paper presents a new approach for a nationally appropriate mitigation actions (NAMA) framework to unlock the potential for greenhouse gas mitigation in dispersed energy end-use sectors in developing countries, more specifically the building and industrial sectors. The author notes that these two sectors make up the largest portion of energy consumption in developing countries. However, due to multiple barriers and lack of effective polices, energy efficiency in dispersed energy end-use sectors has not been effectively put into practice. The new NAMA framework described in the paper is designed to fulfil the demand for public policies and public sector investment in developing countries and thereby boost private sector investment through project based market mechanisms, such as the Clean Development Mechanism (CDM). The framework is designed as a need based mechanism which effectively considers the conditions of each developing country. The building sector is used as an example to demonstrate how NAMA measures can be registered and implemented. The author asserts that the new framework has the ability to interface efficiently with the Kyoto Protocol mechanisms and to facilitate a systematic uptake for greenhouse gas emission reduction investment projects. The author argues that this is an essential step to achieve the global climate change mitigation target and support sustainable development in developing countries.