The handbook contains 31 articles by individual authors covering the following issues: policies and legislation on F-gases and related issues (Part 1), safety concerns and means to overcome (Part 2), a technical assessment of natural refrigerants in different applications (air conditioning, commercial and industrial refrigeration and heat pumps) (Part 3), and case studies by manufacturers and end-users providing insights into market developments and examples of successful conversions to natural refrigerants (Part 4).