This study assessed and evaluated the variation of the health burden in response to extreme weather events (of which climate change is a cause) that occurred in Thailand from 2006 to 2010. The health burden was assessed using disability-adjusted life years (DALYs) lost and deaths from injuries as its indicators. Most of the DALYs in Thailand were lost from floods (approximately 12,872). The authors recommend that future studies should aim to improve and systematize the database systems of agencies that collect health data events occurring due to extreme weather in Thailand, because these databases currently do not cover all of the affected health conditions assessed in studies, such as cause of injury, feature of injuries, and duration of the disability.