Scenario of Moisture Stress in soils and its effects on major crops in South-western region of Bangladesh (grid cell: 22.50N - 25.0N, 87.50E - 90.00ooE) has been assessed based on climate scenarios for two projection years 2030 and 2075 compared to the 1990 baseline. The climate scenarios were developed using an ensemble of 15 GCM outputs by using MAGICC/SCENGEN version 5.3 model of the IPCC. Then CROPWAT model developed by the FAO was used to predict the soil moisture deficit (SMD) for the projected climate scenarios to assess crop water requirement (CWR) and variation in yield of the main rain fed crops in the said region.