This report presents important knowledge on Ghana’s vulnerability to climate change and various adaptation options that could be integrated into sectoral and spatial planning. It provides the needed inputs for planning a sustainable future. The need to pay attention to community-level actions/responses through direct support and mainstreaming into national policy cannot be overemphasized. This study seeks to: Identify some robust adaptation strategies and options at the local level. Provide a basis for understanding how to structure adaptation interventions so as to benefit the most vulnerable households and communities within vulnerable regions. Assess the impact of socioeconomic status, gender, and poverty in shaping a range of types of vulnerability of different social groups to climate change. Provide cost-benefit estimates for alternative adaptation responses in different agroecological zones.