This multi-year research project is designed to simulate operations of the largest power system in the world with high penetrations of wind and solar generation. The study is intended to inform critical questions on how system operations could be impacted by various wind and solar deployment strategies and operational paradigms. It is the first study to simulate the entire Eastern Interconnection and Hydro-Québec with hourly day-ahead unit commitment, five-minute real-time dispatch, and a nodal DC-power flow.