This policy brief outlines high-level issues related to the deployment of carbon capture and sequestration (CCS). It broadly introduces some key challenges that must be addressed for wide-scale deployment of CCS. Selected challenges facing the technology include developing a policy driver to incentivize deployment; defining a ﬂexible and adaptable regulatory framework; and funding large-scale demonstration projects to resolve technical and integration uncertainties as well as reduce high costs. Addressing these three challenges will help solve a fourth challenge: public acceptability. According to the brief, debate over the timing of CCS deployment is likely to continue, but this climate mitigation option is clearly critical to eventual stabilization of greenhouse gas concentrations in the atmosphere.