Cambodia has been identified as one of the most vulnerable countries to climate change, given the predicted changes in temperature and precipitation, the share of labor in agriculture, and the country’s low adaptive capacity due to widespread poverty. In this study, we use climate data from four general circulation models (GCMs) to evaluate the impact of climate change on agriculture in Cambodia by 2050. We used the Decision Support System for Agrotechnology Transfer crop modeling software to evaluate crop yields, first for the 1950–2000 period (actual climate) and then for the climates given by the four GCMs for 2050.