Agriculture is a key sector providing economic and social development in Southeast Asian countries, where a majority of the region’s population depend on agricultural production as a main source of household income. The implication of global environmental change has extended the agricultural agenda to respond to the drivers of climate change—in the context where agriculture is both a contributor to greenhouse gas (GHG) emissions and a possible mitigating factor through the adjustment of practices and the adoption of new technologies. This paper identifies several policy options to stimulate increased innovation, transfer and adoption of relevant agricultural technologies:  Contextual adaptation of technological innovations that bridge innovation with indigenous practices  Investing in better information and forecasts combining ICT4D Support for competitive and responsive agricultural markets Increasing private sector investment in public agricultural research and development through new market mechanism and partnerships Increasing the reach of technological diffusion to the poorest of smallholders with technologies that are appropriate to their scale of agriculture Strengthening policies that address both the protection of Intellectual Property and the fair exercise of traditional humanitarian rights of smallholder farmers Streamlining cooperation for technological diffusion and research with countries outside Southeast Asia but within the same agroecological zone.