This article argues that the delay in combating climate change is attributable to various factors, including polarised interests among nations. However, the Montreal Protocol on Substances that Deplete the Ozone Layer has managed to balance and reconcile the interests of both southern and northern countries towards a common goal. Although differences exist, lessons from the ozone depletion regime can inform the climate regime and enhance the participation of developing nations without adversely affecting their interests. The lessons outlined in this article include: address the most critical issue (i.e. emission from developed countries) first; increase participation and compliance; improve financial assistance and technology transfer regimes; and enhance political commitment to tackling climate change. These lessons are in tune with the principle of common but differentiated responsibilities which should facilitate a meaningful participation of developing countries in the regime.