Background: Our Universal Chiral Catalysts can facilitate a variety of enantiomeric selective reactions including Aldol condensations Mannich reactions Michael additions Diels-Alder and other cycloaddition reactions alpha-aminations alpha-aminoxylations and Friedel-Crafts alkylations. These catalysts present a significant proprietary advantage in reducing the cost and improving the quality of pharmaceutical supplies. In addition elegant synthetic schemes for several pharmaceutically significant classes of compounds are being developed. Technology Description: Our technology is a new class of organocatalysts for the synthesis of single-enantiomer compounds. Our Universal Chiral Catalysts can facilitate a variety of enantiomeric selective reactions including Aldol condensations Mannich reactions Michael additions Diels-Alder and other cycloaddition reactions alpha-aminations alpha-aminoxylations and Friedel-Crafts alkylations. These catalysts present a significant proprietary advantage in reducing the cost and improving the quality of pharmaceutical supplies. In addition elegant synthetic schemes for several pharmaceutically significant classes of compounds are being developed. Applications: Catalyst across a broad spectrum of chemical processes
1) They are easily prepared more environmentally benign and cheaper since they do not rely on expensive and toxic metals. 2) Generally organocatalysts catalyzed reactions can be performed under an aerobic condition in common even water-containing organic solvents. They are more robust and can be stored and handled in an air atmosphere thus providing operational simplicity.These small organic molecules can be immobilized on a solid support and reused more conveniently than organometallic/bioorganic analogues. 3) They show promising adaptability to high-throughput screening and process chemistry. 4) They are more stable and less expensive than enzymes and bioorganic catalysts and that they are capable of catalyzing a variety of organic reactions with a diverse range of different substrates. 5) Such catalysts can provide high levels of asymmetric induction across a broad spectrum of chemical processes.