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Anti-mycotoxin Compound and a Screening Test for Mycotoxin Inhibitors

Mycotoxins metabolites produced by specific fungi are introduced into the food chain by pre-harvest and post-harvest contamination of foods and livestock feed. Infestation of crops and food by mycotoxin producing fungi causes serious immunosuppressive carcinogenic cytotoxic and teratogenic effects in humans and animals. The Aspergillus mycotoxin aflatoxin is the most potent naturally occurring carcinogen and one of the most economically important mycotoxins worldwide. Fusarium mycotoxins infect the grain of developing wheat and maize and include deoxynivalenol and zearalenone which are acutely toxic to humans causing sickness and potentially death. Currently the U.S. Food and Drug Administration limits the allowable amount of mycotoxins in animal feed and food for human consumption but the effect of chronic exposure to low levels of mycotoxins on human health is unknown. In areas of the world where regulations do not exist mycotoxins cause serious health problems.Description :A naturally occuring compound comprised of C18 alkenylene piperidine amide that inhibits mycotoxin production specifically aflatoxin and deoxynivalenol (DON) but does not inhibit fungal growth; for use as a post-harvest treatment for seeds nuts and grains. A screening test for compounds that inhibit the production of mycotoxin through interactions with mycotoxin biosynthesis genes for the identification and development of new anti-mycotoxin compounds.Benefits-Anti-mycotoxin compound and screening test-Specific action: Compound specifically targets fungal biosynthesis of mycotoxin not fungal growth. -Provides broad spectrum activity: Compound demonstrates activity against aflatoxin and deoxynivalenol (DON). -Post-harvest application: Compound can be applied to crops and nuts during storage and transportation. -Easy to run and evaluate results: Screening test uses standard TLC system. Inexpensive: Screening test doesn\'t require additional expensive reagents or technology. -Identifies active compound: Screening test can be used in purification schemes to isolate the active compound from the material. -Specific: Screening test targets the biosynthesis of mycotoxin not fungal growth.Applications:The anti-mycotoxin compound has applications in the chemical agricultural food science and nutrition and energy (ethanol production) sectors to inhibit post-harvest fungal mycotoxin production on crops nuts and seeds (for human and animal consumption). It would be applied by growers storage facility personnel and shippers. The screening test has applications in the chemical pharmaceutical veterinary and agricultural sectors for use in the identification and development of new anti-mycotoxin compounds.Development Status:The compound composition is patented but research continues on formula optimiziation. A functional prototype of the screening test is developed. IP Protection Status:US patent 6825216 (issued Nov. 30 2004) US patent 7041678 (issued May 9 2006) A divisional patent is pending. Additional Information:Global information website dedicated to mycotoxins incl. regulations: http://www.knowmycotoxins.com/ General information on mycotoxins and effect on crops and animals: http://www.ces.purdue.edu/extmedia/BP/BP-47.htmlWebsites on US Regulation levels of aflatoxins and DON in human and animal feed: http://www.fda.gov/ora/compliance_ref/cpg/cpgvet/cpg683-100.html

Benefits:

-Anti-mycotoxin compound and screening test-Specific action: Compound specifically targets fungal biosynthesis of mycotoxin not fungal growth. -Provides broad spectrum activity: Compound demonstrates activity against aflatoxin and deoxynivalenol (DON).

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