This study quantifies the possible impacts of climate change on the water resources of Indian river systems within the constraints of the uncertainty of climate change predictions. The study uses the PRECIS daily weather data to determine the spatio-temporal water availability in the river systems. A distributed hydrological mode was used to simulate all the river basins of the country. An analysis was performed to evaluate the severity of droughts and floods and thus identify the vulnerable hotspots that may require attention in view of the climate change in various parts of the country.