This article focuses on cooperative adaptation strategies at the community, water user association, district, and national levels along the Khojabakirgansai, a small transboundary tributary of the Syr Darya in Kyrgyzstan and Tajikistan. Data were collected in the basin through in-depth expert interviews, site visits, and household surveys, and were triangulated with climate change data from the available literature. Basin inhabitants cooperate on extreme events that are exacerbated by climate change, including water scarcity, droughts, and flash floods.